Role of β2‐glycoprotein I in the pathogenesis of the antiphospholipid syndrome

Antiphospholipid syndrome (APS) is typically characterized by increased levels of three classes antiphospholipid antibodies, namely lupus anticoagulant, anti-β2-glycoprotein I (anti-β2GPI), and anticardiolipin antibodies. β2-Glycoprotein (β2GPI) a phospholipid-binding protein composed five domains (DI–V) major antigen in APS. β2GPI expressed on the surfaces several cell types, including endothelial cells, monocytes, trophoblast platelets. Its binding to anti-β2GPI antibody triggers downstream signaling events ultimately exerts variety cellular effects. modulates hemostasis complement system, as well playing an important role APS-associated vascular injury. Therefore, studying will help elucidate pathogenesis APS improve treatment patients with this condition. This review mainly focus structure function β2GPI, its implication